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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
34.55
Human Site:
S467
Identified Species:
54.29
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S467
G
K
L
I
D
I
V
S
S
Q
K
V
W
L
P
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S467
G
K
L
I
D
I
V
S
S
Q
K
V
W
L
P
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S467
G
K
L
I
D
I
V
S
S
Q
K
V
W
L
P
Dog
Lupus familis
XP_852191
460
52810
S451
G
K
L
S
D
V
V
S
S
Q
K
V
W
L
P
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S467
G
K
L
S
D
V
V
S
S
Q
K
V
W
F
P
Rat
Rattus norvegicus
Q91ZN7
476
54410
S467
G
K
L
S
D
I
V
S
S
Q
K
V
W
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
S467
G
K
L
S
D
V
V
S
S
Q
K
L
W
L
P
Chicken
Gallus gallus
Q8AYC9
476
53830
S467
G
K
L
S
D
V
V
S
T
Q
K
V
W
L
P
Frog
Xenopus laevis
Q6DE87
474
53957
A466
K
K
M
D
A
V
V
A
V
Q
K
V
L
P
D
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
S402
Q
K
L
S
D
I
I
S
N
Q
K
V
L
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
N489
R
R
F
I
K
I
K
N
A
L
E
D
I
V
L
Honey Bee
Apis mellifera
XP_623436
467
53927
V455
D
I
I
L
K
G
P
V
T
W
P
I
A
V
A
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
S495
G
G
V
N
V
E
H
S
A
S
S
I
N
V
D
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
V460
D
K
L
P
P
I
I
V
K
G
P
P
L
M
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
L424
Y
K
K
L
S
T
S
L
N
D
V
V
W
K
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
86.6
N.A.
80
86.6
N.A.
80
80
33.3
53.3
N.A.
13.3
0
13.3
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
93.3
93.3
53.3
66.6
N.A.
46.6
33.3
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
7
14
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
0
0
7
60
0
0
0
0
7
0
7
0
0
14
% D
% Glu:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
14
0
% F
% Gly:
60
7
0
0
0
7
0
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
27
0
47
14
0
0
0
0
14
7
0
0
% I
% Lys:
7
80
7
0
14
0
7
0
7
0
67
0
0
7
0
% K
% Leu:
0
0
67
14
0
0
0
7
0
7
0
7
20
40
14
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
7
0
0
0
7
14
0
0
0
7
0
0
% N
% Pro:
0
0
0
7
7
0
7
0
0
0
14
7
0
14
60
% P
% Gln:
7
0
0
0
0
0
0
0
0
67
0
0
0
0
0
% Q
% Arg:
7
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
40
7
0
7
67
47
7
7
0
0
0
7
% S
% Thr:
0
0
0
0
0
7
0
0
14
0
0
0
0
0
0
% T
% Val:
0
0
7
0
7
34
60
14
7
0
7
67
0
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
60
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _